Discover the Potential of Eltrekibart for Treating Hidradenitis Suppurativa

This study is a Phase 2b, double-blind, placebo-controlled trial evaluating Eltrekibart in adult participants with moderate to severe hidradenitis suppurativa.

Kentucky location for dermatology study by Equity Medical
Study Location
Kentucky

Overview

Recruiting start date
  • 10/1/24
Duration
  • 16 Weeks
Study Drug

Eltrekibart

Delivery

Subcutaneous Injection

Sponsor

Eli Lilly and Company

Phase

2

Mechanism of Action

CXCR1 and CXCR2 ligands

Inclusion Criteria
  • Have a diagnosis of HS for at least 12 months.
  • Have HS lesions in at least 2 distinct anatomical regions. At least 1 of the lesions must be at least Hurley Stage II or III.
  • Have an (abscess plus inflammatory nodule) count of at least 5.
  • Agree to use topical antiseptics daily.
  • Had an inadequate response or intolerance to a 28-day course of oral antibiotics.
Exclusion Criteria
  • Have more than 20 draining fistulae.
  • Have had surgical treatment for HS in the last 4 weeks before randomization.
  • Have an active skin disease or condition that could interfere with the assessment of HS.
  • Have a current or recent acute, active infection.
  • Are immunocompromised.
  • Have a history of chronic alcohol abuse, IV drug abuse, or other illicit drug abuse within 1 year before screening.
Important Notes:

This study aims to find the appropriately safe and effective dose and dosing frequency for Eltrekibart in adults with moderate-to-severe hidradenitis suppurativa (HS) for further clinical development. The study will last approximately 62 weeks and may include up to 31 visits.

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